| HIV and antiretroviral therapy: lipid abnormalities and associated cardiovascular risk in HIV-infected patients. | |
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MedLine Citation:
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PMID: 18725816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been demonstrated that patients on highly active antiretroviral therapy are at increased risk for developing metabolic abnormalities that include elevated levels of serum triglycerides and low-density lipoprotein cholesterol and reduced levels of high-density lipoprotein cholesterol. This dyslipidemia is similar to that seen in the metabolic syndrome, raising the concern that highly active antiretroviral therapy also potentially increases the risk for cardiovascular complications. This paper reviews the contribution of both HIV infection and the different components of highly active antiretroviral therapy to dyslipidemia and the role of these abnormalities toward increasing the risk of cardiovascular disease in HIV-infected patients; therapeutic strategies to manage these risks are also considered. |
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Authors:
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Donald P Kotler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 49 Suppl 2 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-26 Completed Date: 2008-10-09 Revised Date: 2010-03-11 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: S79-85 Citation Subset: IM; X |
Affiliation:
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Division of Gastroenterology, Department of Medicine, St. Luke's-Roosevelt Hospital Center, College of Physicians & Surgeons, Columbia University, New York, NY 10025, USA. dpkotler@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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adverse effects* Antiretroviral Therapy, Highly Active / adverse effects Cardiovascular Diseases / complications Dyslipidemias / diet therapy, etiology* HIV Infections / complications*, drug therapy HIV-Associated Lipodystrophy Syndrome / diet therapy, etiology* Humans Lipid Metabolism Lipids / blood Risk |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Lipids |
| Comments/Corrections | |
Comment In:
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J Acquir Immune Defic Syndr. 2010 Mar 1;53(3):419-20
[PMID:
20190590
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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