| HIV-HCV co-infection: epidemiology, pathogenesis and therapeutic implications. | |
| | |
MedLine Citation:
|
PMID: 23111959 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Hepatitis C virus (HCV) is the cause of more than three-quarters of liver-related deaths in HIV-seropositive individuals and it is remarkable that today approximately one-quarter of HIV-infected individuals in Europe and the USA have a HCV coinfection. HIV/HCV coinfected patients were more likely to develop cirrhosis, had an increased risk of developing AIDS, of HIV-related disease and of overall mortality. How HCV may affect the course of HIV infection is not well known even if it was suggested that HCV co-infection is able to increase immune activation and to sensitize CD4+ T-cells towards apoptosis in the absence of HIV therapy. There are many evidences that the simultaneous presence of HIV infection accelerates the liver damage from HCV favouring the evolution to cirrhosis in co-infected patients. HIV increasing of TNF alpha liver production and of HCV replication in peripheral blood lymphomonocytes are the mechanisms at the basis of this phenomenon. HAART had a positive effect on HIV/HCV co-infection, otherwise it does not appear to fully correct the adverse effect of HIV infection on HCV-related outcomes. Traditional treatment with pegilated Interferon plus ribavirin have low rates of sustained virological response in co-infected patients especially if infected with HCV genotype 1, and better results were often obtained in patients in which the use of antiretroviral treatment was avoided to reduce the occurrence of adverse effects. The recent preliminary results on the use of anti-HCV protease inhibitor drugs, boceprevir and telapravir, in co-infected people seems to demonstrate an enhanced antiviral efficacy in the HIV/HCV co-infected population of triple anti-HCV treatment even is some important limitation as interactions with antiretroviral agents and selection of HCV drug resistance, lead to consider the need for further studies designed to assess the best therapeutic strategies. |
| | |
Authors:
|
M Andreoni; A Giacometti; I Maida; P Meraviglia; D Ripamonti; L Sarmati |
Related Documents
:
|
1616319 - Induction of hepatic cyp1a activity as a biomarker for environmental exposure to aroclo... 16103779 - Low incidence of hepatotoxicity in a cohort of hiv patients treated with lopinavir/rito... 18079009 - Development of a suspension serum-free helper-dependent adenovirus production system an... 23223639 - Patterned polymer nanowire arrays as an effective protein immobilizer for biosensing an... 22985479 - Creating genetic resistance to hiv. 23606919 - Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-o... 12487559 - Lack of hcv infection in malignant cells refutes the hypothesis of a direct transformin... 7539829 - Hepatitis b and d genomes in hepatitis b surface antigen negative patients with chronic... 8446779 - Distribution and infection of langerhans cells in the skin of hiv-infected healthy subj... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European review for medical and pharmacological sciences Volume: 16 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 1473-83 Citation Subset: IM |
Affiliation:
|
Clinical Infectious Diseases, Tor Vergata University, Rome, Italy. andreoni@uniroma2.it Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy Clinical Infectious Diseases, Sassari University, Sassari, Italy Second department Infectious Diseases Division, Sacco Hospital, Milano, Italy Ospedali Riuniti di Bergamo, Bergamo, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High reinfection rate of Helicobacter pylori in young type 1 diabetic patients: a three-year follow-...
Next Document: Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TG...