Document Detail


HIV-HBV and HIV-HCV coinfection and liver cancer development.
MedLine Citation:
PMID:  17672044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver diseases caused by chronic HBV or HCV infection, including cirrhosis and HCC, are emerging as an increasingly important problem faced by millions of HIV-infected patients who are coinfected with HBV or HCV. On one hand, HIV-induced immune suppression enhances the risk of chronic viral hepatitis, increases HBV or HCV load, and may hasten the progression to cirrhosis and liver cancer. On the other hand, significant hepatotoxicity is associated with a number of antiretroviral drugs, further exacerbating liver damage associated with chronic viral hepatitis. The exact risk of HCC in HIV and HBV or HCV coinfected patients remains to be fully assessed. The elucidation of the multiple virus-virus and virus-host interactions that underlie viral hepatocarcinogenesis and potential HIV enhancement awaits the establishment of appropriate in vitro and in vivo model systems. As millions of HIV-infected patients in the developing countries are gaining access to HAART therapy for their HIV infections, endemic HBV and HCV infections and their associated liver diseases will only become more problematic on a global level. To ameliorate the suffering from HBV- and HCV-induced liver cancer in HIV patients, more effective treatment for chronic HBV and HCV infections are needed. The long time frame of viral hepatocarcinogenesis may afford a window of opportunity to develop and improve such treatment.
Authors:
Jianming Hu; Laurie Ludgate
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer treatment and research     Volume:  133     ISSN:  0927-3042     ISO Abbreviation:  Cancer Treat. Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-03     Completed Date:  2007-09-26     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  8008541     Medline TA:  Cancer Treat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
HIV / pathogenicity*
HIV Infections / complications,  epidemiology,  therapy,  virology*
Hepacivirus / genetics,  pathogenicity*
Hepatitis B virus / genetics,  pathogenicity*
Hepatitis, Viral, Human / complications,  epidemiology,  virology*
Humans
Liver Neoplasms / pathology*,  virology*
Grant Support
ID/Acronym/Agency:
R01 AI043453/AI/NIAID NIH HHS; R01 AI043453-14/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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