| HIV-Derived Vectors for Gene Therapy Targeting Dendritic Cells. | |
| | |
MedLine Citation:
|
PMID: 22975878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Human immunodeficiency virus type 1 (HIV-1)-derived lentiviral vectors (LV) have the potential to mediate stable therapeutic gene transfer. However, similarly to other viral vectors, their benefit is compromised by the induction of an immune response toward transgene-expressing cells that closely mimics antiviral immunity. LV share with the parental HIV the ability to activate dendritic cells (DC), while lack the peculiar ability of subverting DC functions, which is responsible for HIV immune escape. Understanding the interaction between LV and DC, with plasmacytoid and myeloid DC playing fundamental and distinct roles, has paved the way to novel approaches aimed at regulating transgene-specific immune responses. Thanks to the ability to target either DC subsets LV might be a powerful tool to induce immunity (i.e., gene therapy of cancer), cell death (i.e., in HIV/AIDS infection), or tolerance (i.e., gene therapy strategies for monogenic diseases). In this chapter, similarities and differences between the LV-mediated and HIV-mediated induction of immune responses, with specific focus on their interactions with DC, are discussed. |
| | |
Authors:
|
Maura Rossetti; Mariangela Cavarelli; Silvia Gregori; Gabriella Scarlatti |
Related Documents
:
|
23727238 - Commensal microbiota are required for systemic inflammation triggered by necrotic dendr... 23261828 - The effect of glycyrrhizin on maturation and t cell stimulating activity of dendritic c... 23322088 - Hpnas-4 inhibits proliferation through s phase arrest and apoptosis: underlying action ... 23552418 - Hiv-1 vpu does not degrade the interferon regulatory factor 3. 16339568 - Il-18 induces monocyte chemotactic protein-1 production in macrophages through the phos... 22336588 - Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-mo... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 762 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
|
Created Date: 2012-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 239-61 Citation Subset: IM |
Affiliation:
|
Division of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV Impairment of Immune Responses in Dendritic Cells.
Next Document: Targeting Dendritic Cells for Improved HIV-1 Vaccines.