| HIV-1 mutational patterns in HIV-1 subtype C infected long-term survivors in Karonga District Malawi: correction and further analysis. | |
| | |
MedLine Citation:
|
PMID: 21702696 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Here we present new sequence data from HIV-1 subtype C infected long-term survivors (LTS) from Karonga District, Malawi. Gag and env sequence data were produced from nine individuals each of whom has been HIV-1 positive for more than 20 years. We show that the three amino acid deletion in gag p17 previously described from these LTS is not real and was a result of an alignment error. We find that the use of dried blood spots for DNA-based studies is limited after storage for 20 years. We also show some complex amino acid changes in env C2-V3 in LTS over time and different patterns of genetic divergence amongst LTS. While no clear association between mutations and survival could be shown, amino acid changes that are present in more than one LTS may, in the future, be shown to be important. |
| | |
Authors:
|
Ishla Seager; Michael D Leeson; Amelia Crampin; Dominic Mulawa; Neil French; Judith Glynn; Simon Travers; Grace P McCormack |
Related Documents
:
|
7087796 - Inhibition of medium and short-chain fatty acid oxidation in rat heart mitochondria by ... 12620356 - Homologous very-long-chain 1,3-alkanediols and 3-hydroxyaldehydes in leaf cuticular wax... 1671746 - Expression in escherichia coli, purification and characterization of two mammalian thio... 19090726 - Human cyp4z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. 12241996 - Antioxidant activity in medicinal plants associated with the symptoms of diabetes melli... 23603526 - Involvement of the gabaergic system in the anxiolytic-like effect of the flavonoid ella... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
|
Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
National University of Ireland, Zoology, Galway, Ireland; ishla.seager@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improved Biological Network Reconstruction Using Graph Laplacian Regularization.
Next Document: The use of inflammatory markers as a method for discharging patients post hip or knee arthroplasty.