Document Detail


HIV type 1 mutational patterns in HIV type 1 subtype C-infected long-term survivors in Karonga District Malawi: further analysis and correction.
MedLine Citation:
PMID:  21702696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we present new sequence data from HIV-1 subtype C-infected long-term survivors (LTS) from Karonga District, Malawi. Gag and env sequence data were produced from nine individuals each of whom has been HIV-1 positive for more than 20 years. We show that the three amino acid deletion in gag p17 previously described from these LTS is not real and was a result of an alignment error. We find that the use of dried blood spots for DNA-based studies is limited after storage for 20 years. We also show some unlikely amino acid changes in env C2-V3 in LTS over time and different patterns of genetic divergence among LTS. Although no clear association between mutations and survival could be shown, amino acid changes that are present in more than one LTS may, in the future, be shown to be important.
Authors:
Ishla Seager; Michael D Leeson; Amelia C Crampin; Dominic Mulawa; Neil French; Judith R Glynn; Simon A A Travers; Grace P McCormack
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-30
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  28     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-05-31     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM; X    
Affiliation:
Molecular Evolution and Systematics Laboratory, Zoology, Ryan Institute, School of Natural Sciences, National University of Ireland, Galway, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Female
Genes, env / genetics*
HIV Antigens / genetics*
HIV Long-Term Survivors / statistics & numerical data*
HIV Seropositivity / epidemiology,  genetics*
HIV-1 / genetics*,  isolation & purification
Humans
Malawi / epidemiology
Male
Middle Aged
Molecular Sequence Data
Mutation
Phylogeny
Polymerase Chain Reaction
Sequence Deletion / genetics
gag Gene Products, Human Immunodeficiency Virus / genetics*
Grant Support
ID/Acronym/Agency:
079828//Wellcome Trust; //Wellcome Trust
Chemical
Reg. No./Substance:
0/HIV Antigens; 0/gag Gene Products, Human Immunodeficiency Virus; 0/p17 protein, Human Immunodeficiency Virus Type 1
Comments/Corrections

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