| HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. | |
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MedLine Citation:
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PMID: 23299618 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I-VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a t(1/2) of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.Mucosal Immunology advance online publication 9 January 2013; doi:10.1038/mi.2012.107. |
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Authors:
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N L Yates; A R Stacey; T L Nolen; N A Vandergrift; M A Moody; D C Montefiori; K J Weinhold; W A Blattner; P Borrow; R Shattock; M S Cohen; B F Haynes; G D Tomaras |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-09 |
Journal Detail:
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Title: Mucosal immunology Volume: - ISSN: 1935-3456 ISO Abbreviation: Mucosal Immunol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101299742 Medline TA: Mucosal Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA [2] Department of Medicine, Duke University, Durham, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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