Document Detail


HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE.
MedLine Citation:
PMID:  17457103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses.
Authors:
Sodsai Tovanabutra; Mark de Souza; Nopporn Sittisombut; Somchai Sriplienchan; Vidhaya Ketsararat; Deborah L Birx; Chirasak Khamboonrueng; Kenrad E Nelson; Francine E McCutchan; Merlin L Robb
Related Documents :
3688073 - A thirty-year review of maternal mortality in oklahoma, 1950 through 1979.
3812563 - Partial duplication 16p resulting from a 3:1 segregation of a maternal reciprocal trans...
16437423 - Rescue high frequency jet ventilation versus conventional ventilation for severe pulmon...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  AIDS (London, England)     Volume:  21     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-07-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1050-3     Citation Subset:  IM; X    
Affiliation:
Research Institute for Health Sciences, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
CD4 Lymphocyte Count
Cell Compartmentation
Female
Genetic Variation*
HIV Infections / immunology,  transmission,  virology*
HIV-1 / classification,  genetics*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Phylogeny
Pregnancy
Pregnancy Complications, Infectious / virology*
Prospective Studies
Viral Load
Grant Support
ID/Acronym/Agency:
R01 HD34343-03/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune c...
Next Document:  Steady-state lopinavir levels in third trimester of pregnancy.