| HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE. | |
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MedLine Citation:
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PMID: 17457103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses. |
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Authors:
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Sodsai Tovanabutra; Mark de Souza; Nopporn Sittisombut; Somchai Sriplienchan; Vidhaya Ketsararat; Deborah L Birx; Chirasak Khamboonrueng; Kenrad E Nelson; Francine E McCutchan; Merlin L Robb |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: AIDS (London, England) Volume: 21 ISSN: 0269-9370 ISO Abbreviation: AIDS Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-25 Completed Date: 2007-07-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 1050-3 Citation Subset: IM; X |
Affiliation:
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Research Institute for Health Sciences, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult CD4 Lymphocyte Count Cell Compartmentation Female Genetic Variation* HIV Infections / immunology, transmission, virology* HIV-1 / classification, genetics* Humans Infant, Newborn Infectious Disease Transmission, Vertical Phylogeny Pregnancy Pregnancy Complications, Infectious / virology* Prospective Studies Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD34343-03/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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