Document Detail

HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE.
MedLine Citation:
PMID:  17457103     Owner:  NLM     Status:  MEDLINE    
Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses.
Sodsai Tovanabutra; Mark de Souza; Nopporn Sittisombut; Somchai Sriplienchan; Vidhaya Ketsararat; Deborah L Birx; Chirasak Khamboonrueng; Kenrad E Nelson; Francine E McCutchan; Merlin L Robb
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  AIDS (London, England)     Volume:  21     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-07-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1050-3     Citation Subset:  IM; X    
Research Institute for Health Sciences, Thailand.
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MeSH Terms
CD4 Lymphocyte Count
Cell Compartmentation
Genetic Variation*
HIV Infections / immunology,  transmission,  virology*
HIV-1 / classification,  genetics*
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy Complications, Infectious / virology*
Prospective Studies
Viral Load
Grant Support

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