Document Detail


HIV-1 LTR subtype and perinatal transmission.
MedLine Citation:
PMID:  11531404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple subtypes of HIV-1 have been identified; however, there is little data on the relative transmissibility of viruses belonging to different subtypes. A matched case-control study addressed whether viruses with different long terminal repeat (LTR) subtypes were transmitted equally from mother to infant. The LTR subtype was determined for 45 matched cases and controls who participated in a clinical trial in Tanzania. HIV-1 subtypes A, C, and D and intersubtype recombinant sequences were identified. Exact matched logistic regression analysis showed that viruses containing subtype A or intersubtype recombinant LTRs were 3.2 and 4.8 times more likely to be transmitted from mother to infant than viruses with subtype D LTRs. Viruses containing subtype C LTRs were 6.1 times more likely to be transmitted than those with subtype D LTRs. These differences in transmission were independent of maternal CD4 at enrollment. Thus, it appears that HIV-1 subtype may be associated with differing rates of perinatal transmission in Tanzania.
Authors:
J T Blackard; B Renjifo; W Fawzi; E Hertzmark; G Msamanga; D Mwakagile; D Hunter; D Spiegelman; N Sharghi; C Kagoma; M Essex
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Virology     Volume:  287     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-09-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Female
Fetus / virology
HIV Infections / transmission*,  virology
HIV Long Terminal Repeat / genetics*
HIV-1 / classification,  genetics,  physiology*
Humans
Pregnancy
Recombination, Genetic
Grant Support
ID/Acronym/Agency:
D43 TW00004/TW/FIC NIH HHS; R01 HD32257/HD/NICHD NIH HHS; R01 HD37783/HD/NICHD NIH HHS; R35 CA39805/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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