| HIV-1 integrase sequence variability in antiretroviral naïve patients and in triple-class experienced patients subsequently treated with raltegravir. | |
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MedLine Citation:
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PMID: 20961278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viruses were sequenced from 75 antiretroviral therapy (ARV)-naïve and from 75 ARV-treated patients who subsequently received a raltegravir-containing regimen. No major integrase inhibitor (INI)-resistance mutations were present in the 150 integrase (IN) sequences. Four ARV-naïve (5.3%) and two ARV-treated patients (2.7%) had one of the following minor INI-resistance mutations: L74M, E157Q, G163R, and R263K but there was no association between baseline raltegravir genotype and subsequent response to raltegravir treatment. We also combined our sequences with 4170 previously published group M IN sequences from INI-naïve patients to assess IN sequence variability and compared our findings with those of a study we performed in 2008 using data from 1563 patients. The number of polymorphic IN positions increased from 40% to 41% between the two studies. However, none of the major INI-resistance mutations was found to be polymorphic in either study and there were no significant changes in the prevalence of any of the minor INI-resistance mutations. |
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Authors:
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Vici Varghese; Tommy F Liu; Soo-Yon Rhee; Paolo Libiran; Christina Trevino; W Jeffrey Fessel; Robert W Shafer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-21 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 26 ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-03-15 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 1323-6 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. viciv@stanford.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/HM450153; HM450302 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Amino Acid Substitution / genetics Anti-HIV Agents / therapeutic use* Genetic Variation* HIV Infections / drug therapy*, virology* HIV Integrase / genetics* HIV-1 / genetics*, isolation & purification Humans Molecular Sequence Data Mutation, Missense Pyrrolidinones / therapeutic use* Sequence Analysis, DNA |
| Grant Support | |
ID/Acronym/Agency:
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AI46148-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/MK 0518; 0/Pyrrolidinones; 0/p31 integrase protein, Human immunodeficiency virus 1; EC 2.7.7.-/HIV Integrase |
| Comments/Corrections | |
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