| HIV-1 infection impairs HSV-specific CD4(+) and CD8(+) T-cell response by reducing Th1 cytokines and CCR5 ligand secretion. | |
| | |
MedLine Citation:
|
PMID: 21646911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The concept of HIV-1/HSV-negative immunosynergy has recently come to light, which leads us to explore the impact of HIV-1 infection on HSV-specific T-cell immunity. METHODS: : A combination of interferon (IFN)-γ ELISpot and Luminex-based multicytokine profiling assays was used to compare, in a cross-sectional study, the HSV-specific CD4 and CD8 T-cell responses between 20 HIV-1/HSV-coinfected and 12 HIV-1-uninfected/HSV-infected individuals after in vitro restimulation with HSV glycoprotein D (gD) peptide epitopes. RESULTS: In response to CD4 and CD8 gD peptide epitopes, mean value (±standard errors of the mean) of the different IFN-γ-secreting T cells (ISC) means was significantly reduced in HIV-1/HSV-coinfected individuals (70 ISC ± 10 and 60 ISC ± 8/10 cells) compared with HIV-1-uninfected/HSV-infected individuals (280 ISC ± 25 and 234 ISC ± 23/10 cells, both P < 0.001). After stimulation with the immunodominant CD4 gD and CD8 gD peptide epitopes, the Th1 cytokine and CCR5 ligand secretions were decreased in the HIV-1-infected group although Th17 cytokines increased. The mean concentration of interleukin (IL)-2, IFN-γ, the IFN-γ-induced protein 10 kDa, and the monokine induced by IFN-γ was correlated to the mean concentration of macrophage inflammatory proteins (MIP-1α, MIP-1β), RANTES and Eotaxin (ρ = 0.56, P = 0.02 and ρ = 0.52, P = 0.03). CONCLUSIONS: HIV-1 infection impairs both the number and function of HSV-specific T cells. The downregulation of Th1 cytokines and CCR5 ligands in HIV-1/HSV-coinfected individuals may further facilitate both HSV reactivations and HIV-1 replication. |
| | |
Authors:
|
Pierre-Alain Rubbo; Edouard Tuaillon; Nicolas Nagot; Aziz Alami Chentoufi; Karine Bolloré; Jacques Reynes; Jean-Pierre Vendrell; Lbachir BenMohamed; Philippe Van De Perre |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of acquired immune deficiency syndromes (1999) Volume: 58 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-22 Completed Date: 2011-11-02 Revised Date: 2012-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
|
Languages: eng Pagination: 9-17 Citation Subset: IM; X |
Affiliation:
|
Université Montpellier 1, UMR 1058, 34967 Montpellier, France. pierrealainrubbo@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult CD4-Positive T-Lymphocytes / metabolism, physiology* CD8-Positive T-Lymphocytes / metabolism, physiology* Cytokines / metabolism* Down-Regulation Epitopes / immunology Female HIV Infections / complications, immunology*, virology HIV-1* Herpes Simplex / complications, immunology Humans Ligands Male Middle Aged Receptors, CCR5 / metabolism Simplexvirus / immunology* Th1 Cells / immunology Viral Proteins / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
EY014900/EY/NEI NIH HHS; EY019896/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Epitopes; 0/Ligands; 0/Receptors, CCR5; 0/Viral Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatm...
Next Document: Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention an...