| HIPK2: a versatile switchboard regulating the transcription machinery and cell death. | |
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MedLine Citation:
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PMID: 17245128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals and accordingly HIPK2-guided gene expression programs trigger differentiation and development or alternatively apoptosis. The kinase contributes to the regulation of remarkably diverse pathways such as p53 activation or Wnt signaling. Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2. |
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Authors:
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Marco A Calzado; Florian Renner; Ana Roscic; M Lienhard Schmitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-01-29 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 6 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-03-01 Completed Date: 2007-04-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 139-43 Citation Subset: IM |
Affiliation:
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Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Giessen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / genetics Carrier Proteins / physiology* Cell Death / genetics Cell Differentiation / genetics Gene Expression Regulation, Developmental / physiology Humans Protein-Serine-Threonine Kinases / physiology* Transcription, Genetic / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; EC 2.7.1.-/HIPK2 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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