Document Detail


HIPK2: a versatile switchboard regulating the transcription machinery and cell death.
MedLine Citation:
PMID:  17245128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals and accordingly HIPK2-guided gene expression programs trigger differentiation and development or alternatively apoptosis. The kinase contributes to the regulation of remarkably diverse pathways such as p53 activation or Wnt signaling. Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2.
Authors:
Marco A Calzado; Florian Renner; Ana Roscic; M Lienhard Schmitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-29
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  6     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Giessen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / genetics
Carrier Proteins / physiology*
Cell Death / genetics
Cell Differentiation / genetics
Gene Expression Regulation, Developmental / physiology
Humans
Protein-Serine-Threonine Kinases / physiology*
Transcription, Genetic / physiology*
Chemical
Reg. No./Substance:
0/Carrier Proteins; EC 2.7.1.-/HIPK2 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases

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