Document Detail

HIFU lesion volume as a function of sonication time, as determined by MRI, histology, and computations.
MedLine Citation:
PMID:  20670054     Owner:  NLM     Status:  MEDLINE    
Characterization of high-intensity focused ultrasound (HIFU) systems using ex vivo tissues is an important part of the preclinical testing for new HIFU devices. In ex vivo characterization, the lesion volume produced by the absorption of HIFU energy is quantified as operational parameters are varied. This paper examines the three methods used for lesion-volume quantification: histology, magnetic resonance (MR) imaging, and numerical calculations. The methods were studied in the context of a clinically relevant problem for HIFU procedures--that of quantifying the change in the lesion volume with changing sonication time. The lesion volumes of sonicated samples of porcine liver were determined using the three methods, at focal intensities ranging from 800 W/cm(2) to 1700 W/cm(2) and sonication times between 20 s and 40 s. It was found that histology consistently yielded lower lesion volumes than the other two methods, and the calculated values were below magnetic resonance imaging (MRI) at high applied energies. Still, the three methods agreed with each other to within a +/-10% difference for all of the experiments. Increasing the sonication time produced much larger changes in the lesion volume than increasing the acoustic intensity, for the same total energy expenditure, at lower energy (less than 1000 J) levels. At higher energy levels, (around 1500 J), increasing the sonication time and increasing the intensity produced roughly the same change in the lesion volume for the same total energy expenditure.
Subhashish Dasgupta; Janaka Wansapura; Prasanna Hariharan; Ron Pratt; David Witte; Matthew R Myers; Rupak K Banerjee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  132     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  081005     Citation Subset:  IM    
Department of Mechanical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
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MeSH Terms
Computer Simulation
Dose-Response Relationship, Radiation
High-Intensity Focused Ultrasound Ablation / methods*
Liver / pathology*,  radiation effects,  surgery*
Models, Biological*
Radiation Dosage

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