| HIF prolyl hydroxylase inhibitors for anemia. | |
| | |
MedLine Citation:
|
PMID: 21406036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: The hypoxia-inducible factor (HIF) system mediates the body's response to hypoxia, locally, inducing angiogenesis and a shift to anaerobic metabolism, and systemically, increasing red cell mass in anemia. HIF prolyl hydroxylases (HIF-PH) modify HIF, decreasing its activity. Increasing HIF activity through inhibition of HIF-PH may provide an alternative treatment for anemia and may protect against damage related to ischemia-reperfusion. Areas covered: The review discusses the basic science underpinnings of the HIF system and the clinical effects of the HIF system and its pharmacologic manipulation. Expert opinion: Manipulation of the HIF system may improve outcomes in anemia by bypassing the effective iron deficiency found in anemia of chronic disease and by increasing red cell mass without supraphysiologic increases in erythropoietin. HIF-PH may also find a clinical use in the prevention of ischemia-reperfusion damage in strokes, cardiac ischemia, ischemic renal failure, etc. |
| | |
Authors:
|
Eugene Muchnik; J Kaplan |
Related Documents
:
|
3704326 - Ovine enzootic abortion: experimental studies of immune responses. 21554516 - Key two-component regulatory systems that control biofilm formation in pseudomonas aeru... 9578326 - Pyretic and antipyretic signals within and without fever: a possible interplay. 21297896 - Neuroimmunomodulation and aging. 1245236 - Biochemical pathology of lung damage produced by chemicals. 12810106 - Molecular evolution of cxc chemokines: extant cxc chemokines originate from the cns. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Expert opinion on investigational drugs Volume: - ISSN: 1744-7658 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA kaplanjm@umdnj.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Toll-like receptor modulators: a patent review (2006 - 2010).
Next Document: New targeted therapies for gastric cancer.