Document Detail

HIF-mediated endothelial response during cancer progression.
MedLine Citation:
PMID:  22562456     Owner:  NLM     Status:  MEDLINE    
Tumour growth at primary or secondary extravasation sites leads to localised regions of reduced oxygen tension (hypoxia) in cells both within and surrounding the tumour. Although the angiogenic response of the tumour cell to hypoxia has been widely examined, the effect of hypoxia on other cell types within the tumour microenvironment is less clear. The endothelium is highly responsive to local hypoxia and regulates tumour cell dissemination and ultimately metastatic success through differential regulation of hypoxia-inducible transcription factors (HIFs). The endothelial response to hypoxia particularly mediates key processes that regulate tumour vascularisation and cancer progression, including proliferation, migration, adherence, and vascular permeability. This article describes current understanding of the HIF-mediated endothelial response to hypoxia during cancer progression. Endothelial HIF signalling regulates tumour growth and metastasis and is therefore an attractive putative target for treatments that inhibit cancer progression.
Colin E Evans; Cristina Branco-Price; Randall S Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-08
Journal Detail:
Title:  International journal of hematology     Volume:  95     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-09-07     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
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MeSH Terms
Anoxia / metabolism*,  pathology
Endothelial Cells / metabolism,  pathology*
Hypoxia-Inducible Factor 1 / metabolism*
Neoplasm Metastasis / pathology
Neoplasms / blood supply,  metabolism*,  pathology*
Oxygen / metabolism
Signal Transduction
Grant Support
092738//Wellcome Trust; //Wellcome Trust
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1; S88TT14065/Oxygen

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