Document Detail

HFE gene mutation and transferrin saturation in very low birthweight infants.
MedLine Citation:
PMID:  10448186     Owner:  NLM     Status:  MEDLINE    
AIM: To determine if there is an association between high transferrin saturation and the C282Y HFE gene mutation in very low birthweight (VLBW) infants. METHODS: One hundred and forty three VLBW infants receiving recombinant erythropoietin and 3 to 9 mg/kg/day of enteral iron were studied. Genomic DNA was extracted from filter paper cards. The C282Y mutation was determined by restriction fragment length polymorphism analysis. RESULTS: Six infants were heterozygous for the mutation; none was homozygous. Ten infants had a transferrin saturation above 80% at least once. No infant was positive for both transferrin saturation above 80% and the mutation. CONCLUSIONS: The data strongly suggest that there is no association between high transferrin saturation and the HFE gene mutation in VLBW infants during the first weeks of life.
R F Maier; H Witt; C Bührer; E Mönch; E Köttgen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  81     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-24     Completed Date:  1999-09-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F144-5     Citation Subset:  AIM; IM    
Department of Neonatology Charité Virchow Hospital Humboldt University D-13353 Berlin Germany.
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MeSH Terms
HLA Antigens / genetics*
Histocompatibility Antigens Class I / genetics*
Infant, Newborn
Infant, Very Low Birth Weight / blood*
Membrane Proteins*
Prospective Studies
Retrospective Studies
Transferrin / metabolism*
Reg. No./Substance:
0/HFE protein, human; 0/HLA Antigens; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins; 11096-37-0/Transferrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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