Document Detail

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes.
MedLine Citation:
PMID:  23018291     Owner:  NLM     Status:  Publisher    
In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes, into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal interaction with lymphocytes. This continuous trafficking of immune cells into and out of lymph nodes is essential for immune surveillance of foreign invaders. In this article, we review our current understanding of the functions of high endothelial venules (HEVs), stroma and lymphatics in the entry, positioning and exit of immune cells in lymph nodes during homeostasis, and we highlight the unexpected role of dendritic cells in the control of lymphocyte homing through HEVs.
Jean-Philippe Girard; Christine Moussion; Reinhold Förster
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  -     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), 205 Route de Narbonne, F-31077 Toulouse, France. [2] Universit de Toulouse, UPS, IPBS, F-31077 Toulouse, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Brain Natriuretic Peptide Is Associated with Worsening and Mortality in Acute Stroke Patients but Ad...
Next Document:  Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid a...