Document Detail


The HERITAGE family study. Aims, design, and measurement protocol.
MedLine Citation:
PMID:  7674877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The HERITAGE family study (HEalth, RIsk factors, exercise Training And GEnetics) will document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise training. A consortium of five universities in the United States and Canada are involved in carrying out the study. A total of 90 Caucasian families and 40 African-American families with both parents and three or more biological adult offspring are being recruited, tested, exercise-trained in the laboratory with the same program for 20 wk, and re-tested. Oxygen uptake, respiratory exchange ratio, blood pressure, heart rate, cardiac output, blood lactate, glucose, and free-fatty acids are measured during exercise, and maximal oxygen uptake is determined before and after training. Plasma lipids, lipoproteins and apoproteins, glucose and insulin response to an intravenous glucose load, plasma sex steroids and glucocorticoids, and body fat and fat distribution are assessed. Dietary and activity habits and other life style components are assessed by questionnaires, prior to, during, and after training. A variety of genetic analyses will be undertaken, including heritability studies and major gene effects, for each phenotype and its response to regular exercise. Cell lines are established, and DNA sequence variation at a variety of molecular markers will be determined for association and linkage studies.
Authors:
C Bouchard; A S Leon; D C Rao; J S Skinner; J H Wilmore; J Gagnon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  27     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-17     Completed Date:  1995-10-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM; S    
Affiliation:
Physical Activity Sciences Laboratory, Laval University, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group
Aged
Blood Glucose
European Continental Ancestry Group
Exercise / physiology*
Female
Genetic Markers
Genotype*
Hemodynamics
Humans
Lactates / blood
Lactic Acid
Life Style
Lipids / blood
Male
Middle Aged
Oxygen Consumption
Grant Support
ID/Acronym/Agency:
HL45670/HL/NHLBI NIH HHS; HL47317/HL/NHLBI NIH HHS; HL47323/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Genetic Markers; 0/Lactates; 0/Lipids; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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