| The HERITAGE Family Study: quality assurance and quality control. | |
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MedLine Citation:
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PMID: 8978882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The HERITAGE (HEalth, RIsk factors, exercise Training And GEnetics) Family Study is the first multicenter family clinical trial of its kind. Conducted by a consortium of five universities in the United States and Canada, the study has as its primary goal to document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise training. A comprehensive protocol was implemented at four Clinical Centers (CC) for the generation of data on sedentary subjects. This group included 450 caucasians from 90 nuclear families (father, mother, three children) and 200 black subjects from 40 to 100 family units over a 5-year period. The entire family was tested before and after a 20-week exercise training program. The fifth participating center, the Data Coordinating Center (DCC), is responsible for data management and data analysis. A Consortium Coordinating Center (CCC) responsible for the overall coordination and direction of the study was established at the Quebec CC. Quality assurance and quality control are jointly coordinated by the CCC and the DCC. A multicenter study of this magnitude requires careful standardization of all procedures and constant monitoring of quality control at all levels of operation. This report describes the quality assurance and quality control measures implemented in the HERITAGE Family Study, including some examples with real data. |
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Authors:
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J Gagnon; M A Province; C Bouchard; A S Leon; J S Skinner; J H Wilmore; D C Rao |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of epidemiology Volume: 6 ISSN: 1047-2797 ISO Abbreviation: Ann Epidemiol Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-04-11 Completed Date: 1997-04-11 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 9100013 Medline TA: Ann Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 520-9 Citation Subset: IM |
Affiliation:
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Physical Activity Sciences Laboratory, Laval University, Quebec, P.Q., Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiovascular Diseases / genetics*, prevention & control Child Child, Preschool Clinical Trials as Topic* / standards Diabetes Mellitus, Type 2 / genetics*, prevention & control Exercise Family Female Hemodynamics / physiology Humans Life Style* Male Middle Aged Multicenter Studies as Topic* / standards Quality Control Reproducibility of Results Research Design* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL45670/HL/NHLBI NIH HHS; HL47317/HL/NHLBI NIH HHS; HL47323/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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