Document Detail

HER2 targeted therapies for cancer and the gastrointestinal tract.
MedLine Citation:
PMID:  19519356     Owner:  NLM     Status:  MEDLINE    
HER2 (v-erb-b2 erythroblastic leukemia viral oncogene) is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Since the discovery of a role for HER2 and other EGF receptors in the development and progression of cancer, they have become targets for a number of targeted anti-cancer drugs. These drugs have proven to be effective in treating and managing a range of cancers, however, recent observations in the clinic have suggested that their administration causes many toxicities, including gastrointestinal toxicity. Drugs with HER2 inhibitory activity fall into two categories; the monoclonal antibodies and small molecule tyrosine kinase inhibitors. Both of these drug classes have been shown to induce symptoms consistent with mucositis development; including nausea and vomiting, diarrhoea and abdominal pain. However, to date, limited studies have been carried out to justify the source of these toxicities. This review summarizes our current knowledge of the toxicities associated with commonly used HER2 targeted therapy drugs, the role of HER2 in cancer and the healthy gastrointestinal tract and the possible mechanisms by which drugs with HER2 inhibitory activity can induce gastrointestinal damage and possibly mucositis in patients.
Noor Al-Dasooqi; Rachel Gibson; Joanne Bowen; Dorothy Keefe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug targets     Volume:  10     ISSN:  1873-5592     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-09-02     Revised Date:  2012-10-12    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  537-42     Citation Subset:  IM    
Department of Medicine, University of Adelaide, Adelaide, Australia.
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MeSH Terms
Antibodies, Monoclonal / adverse effects,  immunology,  pharmacology,  therapeutic use
Antineoplastic Agents / adverse effects*,  pharmacology,  therapeutic use
Gastrointestinal Tract / drug effects*,  metabolism
Mucositis / chemically induced
Neoplasms / drug therapy*,  metabolism*
Protein Kinase Inhibitors / adverse effects,  pharmacology,  therapeutic use
Receptor, erbB-2 / antagonists & inhibitors*,  immunology,  metabolism
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/Protein Kinase Inhibitors; EC protein, human; EC, erbB-2

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