Document Detail


HDL level or HDL function as the primary target in preventive cardiology.
MedLine Citation:
PMID:  22258137     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The risk for myocardial infarction can be reduced by almost 50% solely by lowering LDL cholesterol. Despite success reducing LDL and cholesterol, atherosclerosis and myocardial infarction remain significant challenges. However, mechanisms of the reverse cholesterol transport system might be used more effectively in the foreseeable future. Although the benefit of high HDL cholesterol appears to be obvious, most clinical trials aimed at increasing HDL cholesterol failed to generate convincing results. Therefore, the question arises as to whether indeed only HDL level or perhaps rather more HDL function is of considerable therapeutic relevance. If function is the crucial issue drugs such as CETP (cholesteryl ester transfer protein) activators or SR-B1 (scavenger receptor type B-1) upregulators could be beneficial. These types of drugs could improve HDL metabolism and might have beneficial effects despite the fact that they lower HDL levels. Ongoing studies on next generation CETP inhibitors and nicotinic acid will clarify this question and might help in our struggle against atherosclerosis.
Authors:
J R Schaefer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-20
Journal Detail:
Title:  Herz     Volume:  -     ISSN:  1615-6692     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Dr.-Pohl-Stiftungsprofessur für Präventive Kardiologie, Klinik für Innere Medizin - Kardiologie, UKGM Standort Marburg und Philipps-Universität Marburg, Baldingerstr., 35033, Marburg, Deutschland, juergen.schaefer@uni-marburg.de.
Vernacular Title:
HDL-Spiegel oder HDL-Funktion als primäres Target der präventiven Kardiologie.
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