| HDL-is it too big to fail? | |
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MedLine Citation:
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PMID: 23318230 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The HDL hypothesis has suffered damage in the past few years. Clinical trials have shown that raising HDL cholesterol levels does not improve cardiovascular disease (CVD) outcomes. In addition, Mendelian randomization studies have shown that DNA variants that alter HDL cholesterol levels in populations are unrelated to incident CVD events. Balancing this deluge of negative data are substantial basic science data supporting the concept that raising HDL cholesterol levels reduces CVD risk. Also, functionally relevant HDL subfractions might be more important determinants of risk than overall HDL cholesterol levels. But, while wobbly, the HDL hypothesis is still standing, seemingly too big to fail owing to past intellectual, economic and psychological investments in the idea. |
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Authors:
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Dominic S Ng; Norman C W Wong; Robert A Hegele |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
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Title: Nature reviews. Endocrinology Volume: - ISSN: 1759-5037 ISO Abbreviation: Nat Rev Endocrinol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500078 Medline TA: Nat Rev Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Shuter Wing, Room 3-041, 30 Bond Street, Toronto, ON M5B 1W8, Canada. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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