Document Detail

HDL-cholesterol levels in the Multiple Risk Factor Intervention Trial (MRFIT) by the MRFIT Research Group 1,2.
MedLine Citation:
PMID:  218069     Owner:  NLM     Status:  MEDLINE    
Preliminary data from the Multiple Risk Factor Intervention Trial (MRFIT) have been examined for evidence that the program has an influence on plasma HDL-cholesterol. The overall mean level of this lipoprotein in the initial cohort of 1,084 men was not altered by two years of participation in this risk factor reduction project. However, changes did occur, both upwards and downwards, in some individuals. There were significant negative associations between change in HDL-cholesterol and changes in body mass, VLDL-cholesterol, LDL-cholesterol, and serum thiocyanate (a measure of cigarette smoking exposure); and there was a small positive association with change in reported alcohol intake. Multiple regression analysis revealed each of these associations to be independent of the others. The fat-controlled diet designed to lower total serum cholesterol did not decrease HDL-cholesterol levels. We conclude that conventional risk reduction programs are not likely to lower circulating HDL-cholesterol, and that program components such as weight reduction and smoking cessation may increase the levels.
S Hulley; P Ashman; L Kuller; N Lasser; R Sherwin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  14     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-05-24     Completed Date:  1979-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-123     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking
Cholesterol / blood
Cholesterol Esters / blood*
Lipoproteins, HDL / blood*
Thiocyanates / blood
Reg. No./Substance:
0/Cholesterol Esters; 0/Lipoproteins, HDL; 0/Thiocyanates; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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