Document Detail


HDL-cholesterol levels in the Multiple Risk Factor Intervention Trial (MRFIT) by the MRFIT Research Group 1,2.
MedLine Citation:
PMID:  218069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preliminary data from the Multiple Risk Factor Intervention Trial (MRFIT) have been examined for evidence that the program has an influence on plasma HDL-cholesterol. The overall mean level of this lipoprotein in the initial cohort of 1,084 men was not altered by two years of participation in this risk factor reduction project. However, changes did occur, both upwards and downwards, in some individuals. There were significant negative associations between change in HDL-cholesterol and changes in body mass, VLDL-cholesterol, LDL-cholesterol, and serum thiocyanate (a measure of cigarette smoking exposure); and there was a small positive association with change in reported alcohol intake. Multiple regression analysis revealed each of these associations to be independent of the others. The fat-controlled diet designed to lower total serum cholesterol did not decrease HDL-cholesterol levels. We conclude that conventional risk reduction programs are not likely to lower circulating HDL-cholesterol, and that program components such as weight reduction and smoking cessation may increase the levels.
Authors:
S Hulley; P Ashman; L Kuller; N Lasser; R Sherwin
Related Documents :
21908949 - Effects of flavangenol, an extract of french maritime pine bark on collagen-induced art...
222539 - Influence of hydrochlorothiazide on the plasma levels of triglycerides, total cholester...
7709769 - Intracystic lipidic profile in fibrocystic breast disease.
20231969 - Lipids analysis in hemolymph of african giant achatina fulica (bowdich, 1822) exposed t...
17419879 - The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects.
18932049 - Effect of dietary alpha-ketoglutarate on blood lipid profile during hypercholesterolaem...
10381159 - Combined effect of vegetable protein (soy) and soluble fiber added to a standard choles...
8577229 - Resistant starch is more effective than cholestyramine as a lipid-lowering agent in the...
5837099 - Regulation of cockroach fat-body metabolism by the corpus cardiacum in vitro.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  14     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-05-24     Completed Date:  1979-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-123     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Cholesterol / blood
Cholesterol Esters / blood*
Humans
Lipoproteins, HDL / blood*
Male
Risk
Thiocyanates / blood
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Lipoproteins, HDL; 0/Thiocyanates; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Distribution of high density and other lipoproteins in selected LRC prevalence study populations: a ...
Next Document:  Serum high density lipoprotein and its relationship to cardiovascular disease risk factor variables ...