| HDL cholesterol levels in children with mild hypercholesterolemia: effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene. | |
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MedLine Citation:
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PMID: 20413969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study aimed to examine the changes in serum lipids in children with mild hypercholesterolemia after the use of skim milk or olive-oil-enriched skim milk in their diet and the modulation of lipid levels by the Taq 1B polymorphism in the cholesteryl-ester transfer protein gene. METHODS: Thirty-six prepubertal children with mild hypercholesterolemia were randomly assigned in a crossover design into 2 groups of 16 and 20 individuals. Both groups received, in sequential inverse order, the 2 types of milk for 2 periods of 6 weeks. RESULTS: Carriers of at least 1 B2 allele had an adjusted basal HDL cholesterol level significantly higher than children with the B1B1 genotype (1.291 mmol/l, 95% CI: 1.184-1.397, vs. 1.082 mmol/l, 95% CI: 0.931-1.233; p = 0.027). In contrast, there were no significant differences in the adjusted basal levels of apolipoprotein A-I (B2 carriers: 1.292 g/l, 95% CI: 1.218-1.367; B1B1 genotype: 1.215 g/l, 95% CI: 1.109-1.320; p = 0.223). The intake of olive-oil-enriched skim milk caused significant increases in HDL cholesterol and apolipoprotein A-I, both in B2 (0.089 mmol/l, 95% CI: 0.032-0.146, p = 0.005; 0.55 g/l, 95% CI: 0.012-0.098; p = 0.018) and in B1B1 carriers (0.179 mmol/l, 95% CI: 0.096-0.262; p < 0.001; and 0.095 g/l, 95% CI: 0.032-0.157; p = 0.003). This increase in HDL cholesterol was significantly higher in the B1B1 group (p = 0.049). CONCLUSION: The consumption of skim milk enriched with olive oil increases the HDL cholesterol and apolipoprotein A-I levels in children with hypercholesterolemia, this effect being more intense in carriers of the B1B1 genotype. |
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Authors:
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María Dolores Estévez-González; Pedro Saavedra-Santana; Laura López-Ríos; Ricardo Chirino; Elena Cebrero-García; Luis Peña-Quintana; Pedro Betancor-León |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-04-22 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 56 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 288-93 Citation Subset: IM |
Affiliation:
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Departamento de Enfermería, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, España. mestevez @ denf.ulpgc.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoprotein A-I / blood Cattle Child Cholesterol Ester Transfer Proteins / genetics* Cholesterol, HDL / blood* Cross-Over Studies DNA / genetics Diet Double-Blind Method Energy Intake Female Genotype Humans Hypercholesterolemia / blood*, diet therapy* Lipids / blood Male Milk* / chemistry Motor Activity Plant Oils* Polymorphism, Genetic Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/CETP protein, human; 0/Cholesterol Ester Transfer Proteins; 0/Cholesterol, HDL; 0/Lipids; 0/Plant Oils; 8001-25-0/olive oil; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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