Document Detail


An HDI polyisocyanate aerosol exposure system for large-scale animal experiments.
MedLine Citation:
PMID:  12908857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An exposure system that allows large-scale exposure of animals to 1,6-hexamethylene diisocyanate (HDI)-based polyisocyanates at a stable concentration and aerosol size distribution was developed. The HDI polyisocyanate aerosol is generated by nebulizing a solution of a commercial polyisocyanate product dissolved in acetone. The aerosol is delivered with a constant airflow into a horizontal flow chamber. Complete mixing of aerosol in the chamber is ensured by a circulating fan. This method has been used to generate atmospheres containing HDI polyisocyanates at a concentration of 10.46+/-0.23 mg/m(3) over a 5-hour period. The overall mass median aerodynamic equivalent diameter was found to be 1.42 microm with a geometric standard deviation of 1.26. The HDI monomer concentration was 0.15+/-0.04 mg/m(3). The average chamber acetone concentration was determined to be 2481+/-222 ppm (mean+/-standard deviation). Different HDI polyisocyanate concentrations in the chamber can be achieved by altering the concentration of the commercial polyisocyanate product in acetone and the chamber flow rate. The described exposure system will be useful for performing toxicological studies involving HDI polyisocyanates.
Authors:
Chun-Ting Lee; Halet G Poovey; Mitchell Friedman; Roy J Rando; Gary W Hoyle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  AIHA journal : a journal for the science of occupational and environmental health and safety     Volume:  64     ISSN:  1542-8117     ISO Abbreviation:  AIHA J (Fairfax, Va)     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-11     Completed Date:  2003-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101146781     Medline TA:  AIHA J (Fairfax, Va)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Affiliation:
Section of Pulmonary Diseases, Critical Care and Environmental Medicine, SL-9, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Air Pollutants, Occupational / toxicity*
Animals
Animals, Laboratory
Cyanates / administration & dosage*,  toxicity*
Disease Models, Animal
Environmental Exposure*
Equipment Design
Humans
Toxicity Tests
Chemical
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants, Occupational; 0/Cyanates; 822-06-0/1,6-hexamethylene diisocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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