Document Detail


HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.
MedLine Citation:
PMID:  18472263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.
Authors:
Agustín Valenzuela-Fernández; J Román Cabrero; Juan M Serrador; Francisco Sánchez-Madrid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-09
Journal Detail:
Title:  Trends in cell biology     Volume:  18     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Affiliation:
Departamento de Medicina Física y Farmacología, Facultad de Medicina and Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Tenerife, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication*
Cell Movement*
Cortactin / metabolism
Cytoskeleton / metabolism*
Gene Expression Regulation*
HSP90 Heat-Shock Proteins / metabolism
Histone Deacetylases / metabolism*
Humans
Immune System
Models, Biological
Neoplasm Metastasis
Protein Denaturation
Protein Folding
Tubulin / chemistry
Chemical
Reg. No./Substance:
0/Cortactin; 0/HSP90 Heat-Shock Proteins; 0/Tubulin; EC 3.5.1.98/HDAC6 protein, human; EC 3.5.1.98/Histone Deacetylases

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