Document Detail

HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.
MedLine Citation:
PMID:  18472263     Owner:  NLM     Status:  MEDLINE    
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.
Agustín Valenzuela-Fernández; J Román Cabrero; Juan M Serrador; Francisco Sánchez-Madrid
Related Documents :
19683843 - Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the pcaf h...
20630573 - Combination of suberoylanilide hydroxamic acid and ritonavir is effective against renal...
24040863 - Toxic mechanisms of 3-monochloropropane-1,2-diol on progesterone production in r2c rat ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-09
Journal Detail:
Title:  Trends in cell biology     Volume:  18     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Departamento de Medicina Física y Farmacología, Facultad de Medicina and Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Tenerife, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Communication*
Cell Movement*
Cortactin / metabolism
Cytoskeleton / metabolism*
Gene Expression Regulation*
HSP90 Heat-Shock Proteins / metabolism
Histone Deacetylases / metabolism*
Immune System
Models, Biological
Neoplasm Metastasis
Protein Denaturation
Protein Folding
Tubulin / chemistry
Reg. No./Substance:
0/Cortactin; 0/HSP90 Heat-Shock Proteins; 0/Tubulin; EC protein, human; EC Deacetylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of phenolic wastewater in UASB reactor: effect of nitrogen and phosphorous.
Next Document:  Experiences of critically ill patients in the ICU.