| HD mouse models reveal clear deficits in learning to perform a simple instrumental response. | |
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MedLine Citation:
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PMID: 22512000 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mouse models of Huntington's disease (HD) were trained to acquire one of two simple instrumental responses (a lever press or a nosepoke) to obtain food reinforcement. Animals from several HD strains revealed apparently progressive deficits in this task, being significantly less able than littermate controls to perform the required responses, at ages where motor function is only mildly affected. These data could provide a simple way to measure learning deficits in these mouse models, likely related to the characteristic pattern of neural damage observed in HD mouse models. |
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Authors:
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Stephen Oakeshott; Russell G Port; Jane Cummins-Sutphen; Judy Watson-Johnson; Sylvie Ramboz; Larry Park; David Howland; Dani Brunner |
Publication Detail:
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Type: Journal Article Date: 2011-11-30 |
Journal Detail:
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Title: PLoS currents Volume: 3 ISSN: 2157-3999 ISO Abbreviation: PLoS Curr Publication Date: 2011 |
Date Detail:
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Created Date: 2012-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101515638 Medline TA: PLoS Curr Country: United States |
Other Details:
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Languages: eng Pagination: RRN1282 Citation Subset: - |
Affiliation:
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Principal Scientist at PsychoGenics, Inc.; Research Associate at PsychoGenics Inc; Breeding Manager at PsychoGenics, Inc.; VP, Neurodegenerative Disorders at PsychoGenics, Inc; Director, PreClinical Research, CHDI Foundation, Inc; Director of In Vivo Biology, CHDI Foundation Inc and Senior VP Behavioral R&D at PsychoGenics, Inc. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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