Document Detail


HD mouse models reveal clear deficits in learning to perform a simple instrumental response.
MedLine Citation:
PMID:  22512000     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mouse models of Huntington's disease (HD) were trained to acquire one of two simple instrumental responses (a lever press or a nosepoke) to obtain food reinforcement. Animals from several HD strains revealed apparently progressive deficits in this task, being significantly less able than littermate controls to perform the required responses, at ages where motor function is only mildly affected. These data could provide a simple way to measure learning deficits in these mouse models, likely related to the characteristic pattern of neural damage observed in HD mouse models.
Authors:
Stephen Oakeshott; Russell G Port; Jane Cummins-Sutphen; Judy Watson-Johnson; Sylvie Ramboz; Larry Park; David Howland; Dani Brunner
Publication Detail:
Type:  Journal Article     Date:  2011-11-30
Journal Detail:
Title:  PLoS currents     Volume:  3     ISSN:  2157-3999     ISO Abbreviation:  PLoS Curr     Publication Date:  2011  
Date Detail:
Created Date:  2012-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101515638     Medline TA:  PLoS Curr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  RRN1282     Citation Subset:  -    
Affiliation:
Principal Scientist at PsychoGenics, Inc.; Research Associate at PsychoGenics Inc; Breeding Manager at PsychoGenics, Inc.; VP, Neurodegenerative Disorders at PsychoGenics, Inc; Director, PreClinical Research, CHDI Foundation, Inc; Director of In Vivo Biology, CHDI Foundation Inc and Senior VP Behavioral R&D at PsychoGenics, Inc.
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