Document Detail

HCV infection and B-cell lymphomagenesis.
MedLine Citation:
PMID:  21789042     Owner:  NLM     Status:  In-Data-Review    
Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL). Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis.
Masahiko Ito; Hideki Kusunoki; Keiko Mochida; Kazunari Yamaguchi; Toshiaki Mizuochi
Publication Detail:
Type:  Journal Article     Date:  2011-07-20
Journal Detail:
Title:  Advances in hematology     Volume:  2011     ISSN:  1687-9112     ISO Abbreviation:  Adv Hematol     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504271     Medline TA:  Adv Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835314     Citation Subset:  -    
Department of Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, MusashiMurayama-shi, Tokyo 208-0011, Japan.
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