| HCV infection and B-cell lymphomagenesis. | |
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MedLine Citation:
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PMID: 21789042 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL). Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis. |
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Authors:
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Masahiko Ito; Hideki Kusunoki; Keiko Mochida; Kazunari Yamaguchi; Toshiaki Mizuochi |
Publication Detail:
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Type: Journal Article Date: 2011-07-20 |
Journal Detail:
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Title: Advances in hematology Volume: 2011 ISSN: 1687-9112 ISO Abbreviation: Adv Hematol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504271 Medline TA: Adv Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 835314 Citation Subset: - |
Affiliation:
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Department of Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, MusashiMurayama-shi, Tokyo 208-0011, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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