Document Detail


HCV iatrogenic and intrafamilial transmission in Greater Cairo, Egypt.
MedLine Citation:
PMID:  20947889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To document hepatitis C virus (HCV) intrafamilial transmission and assess its relative importance in comparison to other current modes of transmission in the country with the largest HCV epidemic in the world. HCV intrafamilial transmission was defined as HCV transmission among relatives living in the same household.
DESIGN: Case-control study. Cases were adult patients with acute hepatitis C diagnosed in two 'fever hospitals' of Cairo. Controls were adult patients with acute hepatitis A diagnosed in the same two hospitals, and family members of cases. All consenting household members of cases provided blood for HCV serological and RNA testing. Homology of viral sequences (NS5b region) within households was used to ascertain HCV intrafamilial transmission. Exposures at risk for HCV during the 1-6 months previous to onset of symptoms were assessed in all cases and controls.
RESULTS: From April 2002 to June 2007, 100 cases with acute hepatitis C, and 678 controls (416 household members and 262 patients with acute hepatitis A) were recruited in the study. Factors independently associated with HCV infection and their attributable fractions (AFs) were the following: having had a catheter (OR=5.0, 95% CI=1.4 to 17.8; AF=6.7%), an intravenous perfusion (OR=5.8, 95% CI=2.5 to 13.3; AF=20.1%), stitches (OR=2.0, 95% CI=1.3 to 6.6; AF=10.7%), gum treatment (OR=3.7, 95% CI=1.1 to 11.9; AF=3.8%) and being illiterate (OR=2.4, 95% CI=1.4 to 4.4). Of the 100 cases, 18 had viraemic HCV-infected household members. Three long-married (>15 years) couples were infected with virtually identical sequences and none of the three index patients reported any exposure at risk, suggesting HCV intra-familial transmission.
CONCLUSION: While three new HCV infections out of 100 could be linked to intra-familial transmission, parenteral iatrogenic transmission (dental care included) was accountable for 34.6% of these new infections. Thus, the relative contribution of intrafamilial transmission to HCV spread seems to be limited.
Authors:
A Paez Jimenez; N Sharaf Eldin; F Rimlinger; M El-Daly; H El-Hariri; M El-Hoseiny; A Mohsen; A Mostafa; E Delarocque-Astagneau; M Abdel-Hamid; A Fontanet; M K Mohamed; V Thiers
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  59     ISSN:  1468-3288     ISO Abbreviation:  Gut     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-04     Revised Date:  2012-08-14    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  1554-60     Citation Subset:  AIM; IM    
Affiliation:
Unité d'Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris Cedex 15, France.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Case-Control Studies
Cross Infection / epidemiology,  transmission*
Egypt / epidemiology
Family Health*
Female
Hepacivirus / classification,  isolation & purification
Hepatitis C / epidemiology,  transmission*,  virology
Humans
Male
Middle Aged
Phylogeny
Risk Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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