Document Detail

HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients.
MedLine Citation:
PMID:  9833906     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Hepatitis C virus (HCV) easily undergoes genomic changes, thus accounting for the presence of different genotypes, with different geographic distributions and different outcomes of chronic hepatitis. Type 1b is frequently found in advanced diseases; however, since this genotype is the most prevalent in older patients, the association with advanced age and severity of the disease is confounding. The aim of this study was to assess changes in the prevalence of HCV genotypes by surveying a large population of chronic hepatitis C patients in Northern Italy, and to assess if the high prevalence of genotype 1b in older patients with advanced diseases simply reflects the duration of HCV infection, rather than intrinsic biological properties of HCV. METHODS: We studied 1368 HCV-RNA positive patients, with histologically proven chronic hepatitis. Drug addiction, blood transfusions and sporadically acquired infections represented the risk factors. RESULTS: Genotype 1b, the most prevalent isolate, and genotype 2a were associated with older age, cirrhosis, sporadically-acquired infections and blood transfusion, while types 1a, 3a, and 4 were associated with younger age, chronic persistent hepatitis and drug addiction. Patients with a history of transfusions were divided into four groups depending on the period of transfusion. The prevalence of genotype 1b decreased with time. Type 3a appeared only after 1979. CONCLUSION: The severity of chronic hepatitis C could be related more to the duration of the infection rather than to the intrinsic pathogenicity of HCV genotypes.
L Roffi; A Ricci; C Ogliari; A Scalori; E Minola; G Colloredo; C Donada; R Ceriani; G Rinaldi; B Paris; G Fornaciari; R Morales; P Del Poggio; A Sangiovanni; M Buonocore; V Bellia; P Riboli; M C Nava; F Panizzuti; A Piperno; M Pozzi; P Pioltelli; G Mancia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hepatology     Volume:  29     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  701-6     Citation Subset:  IM    
S. Gerardo Hospital, Monza, Italy.
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MeSH Terms
Aged, 80 and over
Genetic Variation
Genome, Viral*
Hepacivirus / genetics*
Hepatitis C, Chronic / epidemiology,  physiopathology,  virology*
Italy / epidemiology
Middle Aged

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