| HCS regulation in cultured placenta: action of glucose. | |
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MedLine Citation:
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PMID: 494996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of HCS secretion on placenta cultures in the presence of [3H] leucine was studied. When Eagle's medium containing 0.0055 M of glucose per liter is used, it is noted that the HCS increases regularly in the culture medium, whereas it diminishes in the explants. [3H] HCS represents about 50% of the [3H] proteins, and among these proteins HCS is preferentially secreted in the culture medium. The absence of glucose in the medium provokes a decrease in all of the cellular metabolism as well as a decrease in protein and HCS secretions, with an accumulation of preformed HCS in the tissues. An increase in the glucose level in the medium 0.011 and 0.027 M provokes a selective decrease of HCS secretion with an accumulation of preformed HCS in the tissues, determing a long term decrease in HCS synthesis. Insulin added in the mediums (60 microU/ml) does not change the results significantly. The use of structural analogues of the glucose shows that the point of impact of the HCS secretion regulation by the glucose is membranous; however, it seems that at a second stage one or some glucose metabolites also interven. There is no self regulation of HCS secretion in vitro. |
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Authors:
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F Belleville; A Lasbennes; P Nabet; P Paysant |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 92 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1979 Oct |
Date Detail:
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Created Date: 1979-12-18 Completed Date: 1979-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 336-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Culture Media Female Glucose / analogs & derivatives, pharmacology* Humans Insulin / pharmacology Organ Culture Techniques Placenta / metabolism, secretion* Placental Lactogen / biosynthesis, secretion* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 11061-68-0/Insulin; 50-99-7/Glucose; 9035-54-5/Placental Lactogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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