Document Detail


HCMV seroprevalence and associated risk factors in pregnant women, Havana City, 2007 to 2008.
MedLine Citation:
PMID:  20715119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To prenatally identify pregnant women at risk of developing congenital infection due to human cytomegalovirus (HCMV).
METHODS: One thousand one hundred and thirty-one pregnant women from three municipalities from Havana City were serologically screened for HCMV infection (IgM/IgG, IgG avidity) from January 2007 to January 2008. Demographical, epidemiological, and clinical variables were correlated to serologic status to identify predictors of seroconversion in pregnancy.
RESULTS: The majority of women were seropositive to HCMV (92.6%); 27 women (2.4%) developed HCMV active infection during pregnancy, defined by the detection of IgG+ and IgM+ (7 women), IgM+ and IgG- (2 women), and IgG seroconversion (18 women). Susceptibility of active HCMV infection during pregnancy was associated with maternal age < 20 years and nulligravidity. Primary infection was detected in 20 pregnant women (1.8%), whereas 7 patients (0.6%) had active non-primary infection.
CONCLUSION: Although pregnant women in Cuba have high seroprevalence rates for HCMV, those younger than 20 years and nulligravidae are at risk of acquiring infection during pregnancy.
Authors:
C B Correa; V Kourí; D Verdasquera; P A Martínez; A Alvarez; Y Alemán; L Pérez; J Viera; R González; E Pérez; I Moro; M A Navarro; P Melin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  888-92     Citation Subset:  IM    
Copyright Information:
(c) 2010 John Wiley & Sons, Ltd.
Affiliation:
Virology Department, Institute of Tropical Medicine Pedro Kourí, Havana City, Cuba.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Cuba / epidemiology
Cytomegalovirus Infections / epidemiology*
Female
Follow-Up Studies
Humans
Pregnancy
Pregnancy Complications, Infectious / epidemiology*
Seroepidemiologic Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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