Document Detail


HBx expression activates RhoA GTPase: impact on cell migration.
MedLine Citation:
PMID:  20977432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HBV (hepatitis B virus) remains a global health concern, especially in developing countries. It has been associated with the development of HCC (hepatocellular carcinoma). One of the four viral proteins, HBx, interacts with cellular proteins, which are involved in a series of cellular processes including cell migration. The Rho GTPases (guanine nucleotide triphosphatases) family of proteins is involved in the regulation of the reorganization of actin and cell migration. We have reported that HBV replication activates Rac1 through SH3 binding. Here, we reported that RhoA was activated by HBx in vitro. The cell motility was enhanced in HepG2 cells co-transfected with HBx and RhoA, compared with those transfected with RhoA alone. Our results were consistent with the recently reported role of RhoA in promoting cell motility and may provide new insights on the mechanism of HBV-associated HCC.
Authors:
Huixing Feng; Xi Li; Dandan Niu; Wei Ning Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  35     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-05-03     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Cell Movement
Genotype
Hep G2 Cells
Hepatitis B virus / metabolism*
Humans
Trans-Activators / genetics,  metabolism*
Transfection
rhoA GTP-Binding Protein / genetics,  metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Actins; 0/Trans-Activators; 0/hepatitis B virus X protein; EC 3.6.5.2/rhoA GTP-Binding Protein

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