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HBx and c-myc cooperate in the up-regulation of ribosome biogenesis and in cellular transformation.
MedLine Citation:
PMID:  22889122     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Viral and cellular oncogenes are well known to enhance rRNA synthesis leading to increased ribosome biogenesis and cell proliferation. Our study on molecular underpinnings of the interaction between viral HBx and c-myc genes which is implicated in development of hepatocellular carcinoma, showed a marked increase in biosynthesis of rRNA, ribosomes and protein in hepatoma cells. A profound alteration in the nucleolar morphology and biochemical content of these cells was also observed. Increased biosynthetic activity was associated with increased cell proliferation and transformation of immortalized human hepatocytes. Further, inhibition of RNA polymerase III activity impaired the proliferative advantage of hepatoma cells and transformation of immortalized hepatocytes as effectively as cisplatin treatment. These findings were corroborated in a transgenic HBx-myc microenvironment where elevated hepatic level of rRNAs was associated with conspicuous morphological and biochemical changes in the hepatocytic nucleoli. Thus, HBx and c-myc seem to work cooperatively to support ribosome biogenesis and cellular transformation. © 2012 The Authors Journal compilation © 2012 FEBS.
Authors:
Surendra Kumar Shukla; Vijay Kumar
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  The FEBS journal     Volume:  -     ISSN:  1742-4658     ISO Abbreviation:  FEBS J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229646     Medline TA:  FEBS J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Journal compilation © 2012 FEBS.
Affiliation:
Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
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