| HBsAg-negative mono-infection with hepatitis B virus genotype G. | |
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MedLine Citation:
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PMID: 21114585 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Summary. Infection with a genotype G strain of hepatitis B virus (HBV-G) often occurs as a co-infection with HBV genotype A. In mono-infection with HBV-G, the production of hepatitis B surface antigen (HBsAg), HBe antigen and anti-HBe seems diminished, hampering the serological diagnosis of HBV-G mono-infection. To corroborate this notion, we studied in detail a series of samples of a blood donor with transient HBV-G infection. In this donor, during the temporary presence of HBV DNA and the seroconversion to HBcore antibodies (anti-HBc), no HBsAg or hepatitis B e antigen was detected. During follow-up, no anti-HBe appeared. Multiple resistance mutations to lamivudine were present, demonstrating primary infection with a resistant HBV strain. Cloning and sequencing indicated that no other HBV genotype but genotype G was present. Like other HBV-G isolates, the DNA sequence of the HBsAg a-determinant showed no mutations that could explain the failure to detect HBsAg. Our findings demonstrate that HBV genotype G mono-infection occurs and that routine serology is unsuitable for its detection. |
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Authors:
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H L Zaaijer; H J Boot; P van Swieten; M H G M Koppelman; H T M Cuypers |
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Publication Detail:
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Type: Journal Article Date: 2010-11-29 |
Journal Detail:
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Title: Journal of viral hepatitis Volume: 18 ISSN: 1365-2893 ISO Abbreviation: J. Viral Hepat. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435672 Medline TA: J Viral Hepat Country: England |
Other Details:
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Languages: eng Pagination: 815-9 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Blood-borne Infections, Sanquin, Amsterdam Clinical Virology (CINIMA), Academic Medical Center, Amsterdam Laboratory for Infectious Disease and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven Virology Department, Sanquin, Amsterdam National Screening Laboratory, Sanquin, Amsterdam, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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