Document Detail

HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(-) mothers.
MedLine Citation:
PMID:  21167773     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hepatitis B virus infection is an important public health problem worldwide and eliminating mother-to-infant transmission is important to decrease the prevalence of chronic HBV-infection. Although, immunoprophylaxis given at birth largely prevents mother-to-infant transmission, perinatal HBV viremia has been reported in HBsAg(-) newborns born mainly to HBeAg(+) women in endemic areas.
OBJECTIVES: To examine the incidence of perinatal HBV viremia in newborns of HBsAg(+) predominantly HBeAg(-) mothers.
STUDY DESIGN: Peripheral blood was obtained at birth from 109 HBsAg(+) mothers and their newborns before the administration of active-passive immunoprophylaxis. Infants were prospectively followed and appropriately vaccinated.
RESULTS: Although most (92.7%) of the HBsAg(+) mothers were HBeAg(-), 73.4% had detectable HBV viremia. Neonatal viremia was detected in 3/8 (37.5%) and 24/101 (23.8%) newborns of HBeAg(+) and HBeAg(-) mothers, respectively (p=0.386). However, HBV-DNA levels were significantly higher in newborns of HBeAg(+) mothers (p=0.025). No child developed chronic HBV infection, but one child had evidence of subclinical hepatitis.
CONCLUSIONS: Although the clinical significance of low viremia levels in almost one in four newborns of HBsAg(+) mothers in a low endemicity area is unclear, it may enhance our understanding of HBV mother-to-infant transmission.
Vassiliki Papaevangelou; Dimitrios Paraskevis; Vassiliki Anastassiadou; Evaggelia Stratiki; Maria Machaira; Irene Pitsouli; Catherine Haida; Petros Drakakis; Klara Stamouli; Aris Antsaklis; Angelos Hatzakis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-16
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  50     ISSN:  1873-5967     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-05-23     Revised Date:  2012-06-07    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  249-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Second Department of Pediatrics, P& A Kyriakou Children's Hospital, Medical School, Athens University, Goudi 11527, Athens, Greece.
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MeSH Terms
Child, Preschool
Follow-Up Studies
Hepatitis B / congenital*,  epidemiology,  virology*
Hepatitis B Surface Antigens / blood
Hepatitis B e Antigens / blood
Hepatitis B virus / isolation & purification*
Infant, Newborn
Pregnancy Complications, Infectious / virology
Prospective Studies
Viral Load
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Hepatitis B e Antigens
Comment In:
J Clin Virol. 2012 Jun;54(2):201   [PMID:  22418455 ]
J Clin Virol. 2012 Jun;54(2):202   [PMID:  22480540 ]

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