Document Detail

HB-EGF: increase in the ischemic rat retina and inhibition of osmotic glial cell swelling.
MedLine Citation:
PMID:  16806064     Owner:  NLM     Status:  MEDLINE    
We determined whether the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in the sensory rat retina alters during ischemia-reperfusion, and whether HB-EGF affects the osmotic swelling which is a characteristic feature of Müller glial cells after ischemia. Transient retinal ischemia was induced by elevation of the intraocular pressure for 1 h. Western blots revealed an upregulation of HB-EGF in the retina at 1, 3, and 7 days after reperfusion. HB-EGF inhibited the swelling of glial cells in retinal slices, via stimulation of the synaptic release of glutamate and subsequent activation of glial metabotropic glutamate receptors which resulted in an autocrine release of purinergic receptor agonists. Finally, activation of A1 receptors resulted in opening of glial K(+) and Cl(-) channels. It is suggested that the increased expression of HB-EGF and the inhibition of glial cell swelling may be parts of a protective role of HB-EGF in the ischemic retina.
Malte Weuste; Antje Wurm; Ianors Iandiev; Peter Wiedemann; Andreas Reichenbach; Andreas Bringmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-21
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  347     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-11     Completed Date:  2006-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-8     Citation Subset:  IM    
Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, Germany.
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MeSH Terms
Cell Size / drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Epidermal Growth Factor / metabolism*,  pharmacology*
Intercellular Signaling Peptides and Proteins
Neuroglia / drug effects*,  pathology*
Optic Neuropathy, Ischemic / etiology,  metabolism*
Osmotic Pressure / drug effects
Papilledema / complications,  metabolism*
Rats, Long-Evans
Retina / drug effects,  metabolism*
Retinal Artery / drug effects,  metabolism
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 149176-25-0/heparin-binding EGF-like growth factor; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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