| HB-EGF inhibition in combination with various anticancer agents enhances its antitumor effects in gastric cancer. | |
| | |
MedLine Citation:
|
PMID: 20871033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Advanced gastric cancer (GC) is one of the most lethal malignancies. Although many anticancer agents exist for the treatment of GC, its prognosis remains extremely poor. Therefore, further development of targeted therapies is required for patients with GC. To assess the role of heparin-binding epidermal growth factor-like growth factor (HB-EGF) as a target for GC therapy, the expression of EGF receptor ligands in GC cell lines, and the antitumor effects of an HB-EGF inhibitor (CRM197) as a single agent and in combination with other anticancer agents was assessed in GC cells. HB-EGF was the predominantly expressed ligand among EGF receptor ligands in all the cells. CRM197 induced significant cell apoptosis. Anticancer agents augmented the secretion of HB-EGF into the medium and simultaneously induced cell apoptosis. Combination of CRM197 with other anticancer agents significantly enhanced cell apoptosis. Additionally, co-administration of CRM197 and paclitaxel resulted in synergistic antitumor effects. These results suggested that HB-EGF is a rational target for GC therapy. |
| | |
Authors:
|
Ayako Sanui; Fusanori Yotsumoto; Hiroshi Tsujioka; Tatsuya Fukami; Shinji Horiuchi; Kyoko Shirota; Toshiyuki Yoshizato; Tatsuhiko Kawarabayashi; Masahide Kuroki; Shingo Miyamoto |
Related Documents
:
|
20828243 - Heat shock protein 10 regulated apoptosis of mouse ovarian granulosa cells. 14555213 - Pleiotropic anti-apoptotic activity of glucocorticoids in ovarian follicular cells. 16912693 - Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 3143-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / pharmacology* Bacterial Proteins / pharmacology Blotting, Western Cell Line, Tumor Culture Media Female Humans Intercellular Signaling Peptides and Proteins* Mice Mice, Inbred BALB C Paclitaxel / pharmacology RNA, Small Interfering Receptor, Epidermal Growth Factor / antagonists & inhibitors, genetics Stomach Neoplasms / pathology* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Bacterial Proteins; 0/Culture Media; 0/Intercellular Signaling Peptides and Proteins; 0/RNA, Small Interfering; 149176-25-0/heparin-binding EGF-like growth factor; 33069-62-4/Paclitaxel; 92092-36-9/CRM197 (non-toxic variant of diphtheria toxin); EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytotoxic Effects of Activated Alveolar Macrophages on Lung Carcinoma Cells via Cell-to-Cell Contact...
Next Document: Preparation of Lipopolysaccharide Derived from Pantoea agglomerans Labeled with Fluorescence as a Tr...