Document Detail


HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study.
MedLine Citation:
PMID:  23343448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Highly active antiretroviral therapy (HAART) has been successful in delaying the progression to AIDS in HIV-1-infected individuals. Exposure to HAART can result in metabolic side effects, such as dyslipidemia, in a subset of recipients. Longitudinal data and frozen peripheral blood mononuclear cell pellets were obtained from 1,945 men enrolled in the Multicenter AIDS Cohort. Individuals were genotyped for ancestry informative markers (AIMs) and stratified by biogeographical ancestry (BGA). Then serum levels of total cholesterol (TCHOL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TRIG) were examined controlling for a number of HIV and HAART-related covariates using multivariate mixed-effects linear regression. HIV-1 infection, in the absence of HAART, was associated with altered lipid levels for all phenotypes tested when compared to HIV-negative men. HIV-1-infected men receiving HAART also had significantly different lipid levels compared to HIV-negative men, except for LDL-C. There were statistically significant interactions between BGA and HIV/HAART status for all lipids tested. BGA remained significantly associated with lipid levels after controlling for other HIV and HAART-related covariates. There was low concordance between self-reported race (SRR) and BGA in admixed populations. BGA performed better than SRR in our statistical models. Lipid profiles in untreated HIV-1-positive men and HIV-1-positive men receiving HAART differ from HIV-negative men and this effect varies by BGA. BGA performed better in our statistical analysis as a racial classifier but SRR remains a good clinical surrogate for BGA.
Authors:
Matthew J Nicholaou; Jeremy J Martinson; Alison G Abraham; Todd T Brown; Shehnaz K Hussain; Steven M Wolinsky; Lawrence A Kingsley
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-03-08
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-08-30     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  871-9     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active / adverse effects*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cohort Studies
Continental Population Groups / genetics,  statistics & numerical data*
Dyslipidemias / chemically induced*
Genotype
HIV Infections / blood,  drug therapy*
HIV-1
Humans
Linear Models
Male
Middle Aged
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
K07 CA140360/CA/NCI NIH HHS; U01 AI035041/AI/NIAID NIH HHS; U01-AI-35042/AI/NIAID NIH HHS; UL1 TR000005/TR/NCATS NIH HHS; UL1-RR025005/RR/NCRR NIH HHS; UO1-AI-35039/AI/NIAID NIH HHS; UO1-AI-35040/AI/NIAID NIH HHS; UO1-AI-35041/AI/NIAID NIH HHS; UO1-AI-35043/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 97C5T2UQ7J/Cholesterol
Comments/Corrections

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