Document Detail


HA-1077 suppress both proliferation of vascular smooth muscle cells and c-fos mRNA induction.
MedLine Citation:
PMID:  1479648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HA1077 is a newly synthesized vasodilator with unique intracellular calcium antagonistic action. In this study, its effect on the growth of vascular smooth muscle cells (VSMC) stimulated by fetal calf serum was examined. Both the proliferation and [3H]thymidine incorporation into DNA of the growth-arrested VSMC was dose-dependently inhibited by HA1077. The expression of a proto-oncogene, c-fos, which reached the maximum 30 min after addition of serum, was similarly inhibited by this agent in a dose-dependent manner. Thus, HA1077 is expected to be a useful vasodilator agent capable of suppressing the growth of VSMC which is thought to be an important underlying mechanism of atherosclerosis or restenosis after angioplasty.
Authors:
K Sase; Y Yui; R Hattori; M Shirotani; C Kawai; S Sasayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  56     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1229-33     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine* / analogs & derivatives*
Animals
Calcium / antagonists & inhibitors*
Cell Division / drug effects
Genes, fos / drug effects*
Isoquinolines / pharmacology*
Male
Muscle, Smooth, Vascular / cytology,  drug effects*
RNA, Messenger / genetics*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Isoquinolines; 0/RNA, Messenger; 103745-39-7/fasudil; 7440-70-2/Calcium; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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