| H2S generated by heart in rat and its effects on cardiac function. | |
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MedLine Citation:
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PMID: 14684169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydrogen sulfide (H2S), which was considered as a novel gasotransmitter, is produced endogenously from L-cysteine in mammalian brain and vessels, and might be a physiological function regulator to these organs. Here, we showed that mRNA for H2S producing enzyme, cystathionine gamma-lyase, was expressed in myocardial tissues and H2S could endogenously be produced in myocardial tissues. Negative inotropic effect of H2S was proved in present study in vitro and in vivo experiments, and the effect could partly be blocked by glibenclamide, a KATP channel blocker. An intravenous bolus injection of NaHS provoked a decrease in central venous pressure. The present findings suggested that H2S could be endogenously produced by heart tissues, as a physiological cardiac function regulator, mediated by KATP channel pathway. |
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Authors:
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Bin Geng; Jinghui Yang; Yongfen Qi; Jing Zhao; Yongzheng Pang; Junbao Du; Chaoshu Tang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 313 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-19 Completed Date: 2004-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 362-8 Citation Subset: IM |
Affiliation:
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Institute of Cardiovascular Research, Peking University First Hospital, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Blood Pressure Brain / metabolism Cystathionine gamma-Lyase / biosynthesis Dose-Response Relationship, Drug Glyburide / pharmacology Heart / physiology* Heart Rate Hydrogen Sulfide / metabolism*, pharmacology Male Myocardium / enzymology, metabolism* RNA, Messenger / biosynthesis Rats Rats, Wistar Sulfides / antagonists & inhibitors, pharmacology Ventricular Pressure |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Sulfides; 10238-21-8/Glyburide; 16721-80-5/sodium bisulfide; 7783-06-4/Hydrogen Sulfide; EC 4.4.1.1/Cystathionine gamma-Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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