| H2-receptor-mediated vasodilation contributes to postexercise hypotension. | |
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MedLine Citation:
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PMID: 16141376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early (approximately 30 min) postexercise hypotension response after a session of aerobic exercise is due in part to H1-receptor-mediated vasodilation. The purpose of this study was to determine the potential contribution of H2-receptor-mediated vasodilation to postexercise hypotension. We studied 10 healthy normotensive men and women (ages 23.7 +/- 3.4 yr) before and through 90 min after a 60-min bout of cycling at 60% peak O2 uptake on randomized control and H2-receptor antagonist days (300 mg oral ranitidine). Arterial pressure (automated auscultation), cardiac output (acetylene washin) and femoral blood flow (Doppler ultrasound) were measured. Vascular conductance was calculated as flow/mean arterial pressure. Sixty minutes postexercise on the control day, femoral (delta62.3 +/- 15.6%, where Delta is change; P < 0.01) and systemic (delta13.8 +/- 5.3%; P = 0.01) vascular conductances were increased, whereas mean arterial pressure was reduced (Delta-6.7 +/- 1.1 mmHg; P < 0.01). Conversely, 60 min postexercise with ranitidine, femoral (delta9.4 +/- 9.2%; P = 0.34) and systemic (delta-2.8 +/- 4.8%; P = 0.35) vascular conductances were not elevated and mean arterial pressure was not reduced (delta-2.2 +/- 1.3 mmHg; P = 0.12). Furthermore, postexercise femoral and systemic vascular conductances were lower (P < 0.05) and mean arterial pressure was higher (P = 0.01) on the ranitidine day compared with control. Ingestion of ranitidine markedly reduces vasodilation after exercise and blunts postexercise hypotension, suggesting H2-receptor-mediated vasodilation contributes to postexercise hypotension. |
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Authors:
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Jennifer L McCord; Julie M Beasley; John R Halliwill |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-09-01 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 100 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-16 Completed Date: 2006-02-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Affiliation:
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Department of Human Physiology, 122 Esslinger Hall, 1240 University of Oregon, Eugene, Oregon 97403-1240, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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drug effects Adult Blood Flow Velocity / drug effects Blood Pressure / drug effects Exercise Test / adverse effects* Female Histamine H2 Antagonists / administration & dosage Humans Hypotension / etiology, physiopathology* Male Muscle, Skeletal / blood supply*, drug effects, physiopathology* Physical Exertion* Ranitidine / administration & dosage Receptors, Histamine H2 / metabolism* Vascular Resistance / drug effects Vasodilation* |
| Grant Support | |
ID/Acronym/Agency:
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HL-65305/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Receptors, Histamine H2; 66357-35-5/Ranitidine |
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