Document Detail

H2 receptor antagonists and right ventricular morphology: The MESA Right Ventricle Study.
MedLine Citation:
PMID:  25295642     Owner:  NLM     Status:  Publisher    
Rationale: H2RA use is common and may act directly on the heart through myocardial H2 receptors or indirectly through changes in pulmonary vascular resistance. Objective: To determine the relationship between histamine H2 receptor antagonist (H2RA) use and right ventricular (RV) morphology. Methods: We studied 4,124 participants in the Multi-Ethnic Study of Atherosclerosis without overt cardiovascular disease who had magnetic resonance imaging (MRI) assessment of RV morphology and ascertainment of medication use. Multivariable linear regression estimated cross-sectional associations between H2RA use and RV morphology after adjusting for demographics, anthropometrics, smoking status, diabetes mellitus and hypertension. Further adjustment for co-medication use, left ventricular (LV) parameters, lung structure and function, renal function, or inflammatory markers were considered in separate models. Analyses in a sub-cohort restricted to H2RA or proton pump inhibitor (PPI) users accounted for confounding by the indication of gastroesophageal reflux disease. Measurements and Main Results: H2RA use was associated with lower RV mass (-0.7 g, 95% confidence interval (CI): -1.2 to -0.2 g, p=0.004) and smaller RV end-diastolic volume (EDV) (-4.2 mL, 95% CI: -7.2 to -1.2 mL, p=0.006). This relationship was unchanged with adjustment for co-medication use, lung structure and function, renal function, and inflammation. The relationship with RV mass was independent of LV mass. Results were similar in a smaller sub-cohort restricted to PPI and H2RA users. Conclusion: H2RA use was associated with lower RV mass and smaller RVEDV. This finding is novel. Additional study of histamine and H2 receptors in cardiopulmonary diseases affecting the RV may have direct clinical relevance.
Peter J Leary; R Graham Barr; David A Bluemke; Michael R Bristow; Richard A Kronmal; Joao A Lima; David D Ralph; Corey E Ventetuolo; Steven M Kawut
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-8
Journal Detail:
Title:  Annals of the American Thoracic Society     Volume:  -     ISSN:  2325-6621     ISO Abbreviation:  Ann Am Thorac Soc     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-8     Completed Date:  -     Revised Date:  2014-10-9    
Medline Journal Info:
Nlm Unique ID:  101600811     Medline TA:  Ann Am Thorac Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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