| H1-receptor antagonists. Comparative tolerability and safety. | |
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MedLine Citation:
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PMID: 7913608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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First-generation histamine H1-receptor antagonists, such as diphenhydramine, triprolidine, hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other CNS adverse effects. Second-generation H1-antagonists, such as terfenadine, astemizole, loratadine and cetirizine, represent a true advance in therapeutics. In manufacturers' recommended doses, they have a more favourable benefit/risk ratio than their predecessors with regard to lack of CNS effects, and do not exacerbate the adverse CNS effects of alcohol or other CNS-active chemicals. Rarely, some of the newer H1-antagonists may cause cardiac dysrhythmias after overdose or under other specific conditions. The concept of a risk-free H1-antagonist is proving to be an oversimplification. An H1-antagonist absolutely free from adverse effects under all circumstances is not yet available for use. The magnitude of the beneficial effects of each H1-antagonist should be related to the magnitude of the unwanted effects, especially in the CNS and cardiovascular system, and a benefit-risk ratio or therapeutic index should be developed for each medication in this class. |
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Authors:
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F E Simons |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drug safety : an international journal of medical toxicology and drug experience Volume: 10 ISSN: 0114-5916 ISO Abbreviation: Drug Saf Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-08-25 Completed Date: 1994-08-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002928 Medline TA: Drug Saf Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 350-80 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced Animals Blood-Brain Barrier / drug effects Cardiovascular System / drug effects* Central Nervous System / drug effects* Drug Interactions Electrocardiography / drug effects Electroencephalography / drug effects Ethanol / pharmacology Histamine H1 Antagonists / adverse effects*, toxicity Humans Pharmacoepidemiology Psychomotor Performance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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