Document Detail


H1-receptor antagonists. Comparative tolerability and safety.
MedLine Citation:
PMID:  7913608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
First-generation histamine H1-receptor antagonists, such as diphenhydramine, triprolidine, hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other CNS adverse effects. Second-generation H1-antagonists, such as terfenadine, astemizole, loratadine and cetirizine, represent a true advance in therapeutics. In manufacturers' recommended doses, they have a more favourable benefit/risk ratio than their predecessors with regard to lack of CNS effects, and do not exacerbate the adverse CNS effects of alcohol or other CNS-active chemicals. Rarely, some of the newer H1-antagonists may cause cardiac dysrhythmias after overdose or under other specific conditions. The concept of a risk-free H1-antagonist is proving to be an oversimplification. An H1-antagonist absolutely free from adverse effects under all circumstances is not yet available for use. The magnitude of the beneficial effects of each H1-antagonist should be related to the magnitude of the unwanted effects, especially in the CNS and cardiovascular system, and a benefit-risk ratio or therapeutic index should be developed for each medication in this class.
Authors:
F E Simons
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug safety : an international journal of medical toxicology and drug experience     Volume:  10     ISSN:  0114-5916     ISO Abbreviation:  Drug Saf     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-08-25     Completed Date:  1994-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9002928     Medline TA:  Drug Saf     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  350-80     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced
Animals
Blood-Brain Barrier / drug effects
Cardiovascular System / drug effects*
Central Nervous System / drug effects*
Drug Interactions
Electrocardiography / drug effects
Electroencephalography / drug effects
Ethanol / pharmacology
Histamine H1 Antagonists / adverse effects*,  toxicity
Humans
Pharmacoepidemiology
Psychomotor Performance / drug effects
Chemical
Reg. No./Substance:
0/Histamine H1 Antagonists; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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