Document Detail

H1 and H2 receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women.
MedLine Citation:
PMID:  16888049     Owner:  NLM     Status:  MEDLINE    
In sedentary individuals, H(1) receptors mediate the early portion of postexercise skeletal muscle hyperemia, whereas H(2) receptors mediate the later portion. It is not known whether postexercise hyperemia also presents in endurance-trained individuals. We hypothesized that the postexercise skeletal muscle hyperemia would also exist in endurance-trained individuals and that combined blockade of H(1) and H(2) receptors would abolish the long-lasting postexercise hyperemia in trained and sedentary individuals. We studied 28 sedentary and endurance trained men and women before and through 90 min after a 60-min bout of cycling at 60% peak O(2) uptake on control and combined H(1)- and H(2)-receptor antagonist days (fexofenadine and ranitidine). We measured arterial pressure (brachial auscultation) and femoral blood flow (Doppler ultrasound). On the control day, femoral vascular conductance (calculated as flow/pressure) was elevated in all groups 60 min after exercise (sedentary men: Delta86 +/- 35%, trained men, Delta65 +/- 18%; sedentary women, Delta61 +/- 19%, trained women: Delta59 +/- 23%, where Delta is change; all P < 0.05 vs. preexercise). In contrast, on the histamine antagonist day, femoral vascular conductance was not elevated in any of the groups after exercise (sedentary men: Delta21 +/- 17%, trained men: Delta9 +/- 5%, sedentary women: Delta19 +/- 4%, trained women: Delta11 +/- 11%; all P > 0.16 vs. preexercise; all P < 0.05 vs. control day). These data suggest postexercise skeletal muscle hyperemia exists in endurance trained men and women. Furthermore, histaminergic mechanisms produce the long-lasting hyperemia in sedentary and endurance-trained individuals.
Jennifer L McCord; John R Halliwill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-03
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  101     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-04     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1693-701     Citation Subset:  IM    
Department of Human Physiology, University of Oregon, Eugene, Oregon 97403, USA.
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MeSH Terms
Blood Flow Velocity / drug effects
Exercise Tolerance*
Histamine H1 Antagonists / administration & dosage
Histamine H2 Antagonists / administration & dosage
Muscle, Skeletal / blood supply*,  drug effects,  physiopathology*
Physical Endurance*
Physical Fitness*
Receptors, Histamine H1 / metabolism*
Receptors, Histamine H2 / metabolism*
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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