| H-Gemcitabine: A New Gemcitabine Prodrug for Treating Cancer. | |
| | |
MedLine Citation:
|
PMID: 23237198 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this report we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane impermeable, however it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine. |
| | |
Authors:
|
Niren Murthy; Madhuri Dasari; Abhinav Acharya; Dongin Kim; Seungjun Lee; Sungmun Lee; Jeanne Rhea; Ross Molinaro |
Related Documents
:
|
9283618 - Detection of the receptor for the human urokinase-type plasminogen activator using fluo... 14631378 - Upregulation of tissue inhibitor of metalloproteinases (timp)-2 promotes matrix metallo... 11774278 - Expression of collagenase-3 (mmp-13) enhances invasion of human fibrosarcoma ht-1080 ce... 19125248 - Silencing cd147 inhibits tumor progression and increases chemosensitivity in murine lym... 17121898 - Down-regulation of insulin-like growth factor i receptor activity by nvp-aew541 has an ... 23022528 - The emerging role of t cell cytokines in non-small cell lung cancer. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-14 |
Journal Detail:
|
Title: Bioconjugate chemistry Volume: - ISSN: 1520-4812 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence of long-term structured cuckoo parasitism on individual magpie hosts.
Next Document: Physiological and Molecular Basis of Acetolactate Synthase-Inhibiting Herbicide Resistance in Barnya...