Document Detail


H-2-restricted helper activity mediated by immunoglobulin-bearing lymphocytes.
MedLine Citation:
PMID:  3156178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genetic requirements for helper activity mediated by a unique, Ig-bearing lymphocyte population were studied. This Lyt-1+, I-A+, Thy-1- population, called BH, preferentially helps expression of NPb idiotypic plaque-forming cells when added to T cell-depleted responder cultures. Furthermore, the BH population can directly bind NPb idiotypic determinants. Using H-2 congenic mice, we show that BH helper activity can be expressed only when BH cells share I-A subregion alleles with responder B cell populations. This H-2 restriction is not a result of thymic influences, because the activity of BH cells from athymic mice are also H-2 restricted. Macrophages present in the BH population do not contribute to the H-2 restriction. Results are presented that definitively rule out the possible role for T lymphocytes in BH activity and demonstrate that a single helper population expresses both Lyt-1 and I-A determinants. These results indicate that Ig-bearing cells serve a regulatory as well as an effector role in immune responses and that, like other regulatory lymphoid subsets, their activity is regulated in part by MHC-encoded determinants.
Authors:
D H Sherr; M E Dorf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  134     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-04-23     Completed Date:  1985-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2084-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody-Producing Cells / immunology
Antigens, Ly / analysis
B-Lymphocytes / classification*,  immunology
H-2 Antigens / genetics*,  immunology
Hemolytic Plaque Technique
Histocompatibility Antigens Class II / analysis
Macrophages / classification,  immunology
Male
Mice
Mice, Inbred C57BL
Mice, Nude
Phenotype
Receptors, Antigen, B-Cell*
T-Lymphocytes, Helper-Inducer / immunology*
Grant Support
ID/Acronym/Agency:
AI 16677/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Ly; 0/H-2 Antigens; 0/Histocompatibility Antigens Class II; 0/Receptors, Antigen, B-Cell

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