Document Detail

H-2 class I mutants utilize novel restriction specificities in the trinitrophenyl-specific cytotoxic T-lymphocyte response.
MedLine Citation:
PMID:  2412708     Owner:  NLM     Status:  MEDLINE    
In antigen-specific cytotoxic T-lymphocyte (CTL) responses H-2 class I mutations usually result in a decreased recognition of the antigen in association with the mutant molecule by CTL from the strain of origin. However, the influence of class I mutations on the magnitude and specificity of CTL responses in the mutants has been studied in only a few instances, in which usually a partial or complete loss of responsiveness was found. We now report that class I mutants extensively use gained (novel) CTL restriction sites, generated by the mutations in the CTL response against the hapten trinitrophenyl (TNP), demonstrated both at the population level and in limiting dilution. TNP-specific CTL clones, restricted by mutant-specific determinants, were detected in all mutants. The percentages mutant-specific CTL clones in limiting dilution experiments were 43, 40, 35, and 13 in the Kb mutants bm1, bm8, bm3 and bm5, respectively, and 35 in the Db mutant bm 14. It is concluded that H-2 class I mutations led to changes in the TNP-specific CTL repertoire resulting in gain of CTLs uniquely restricted to the mutant molecule.
C J Boog; L P de Waal; H T Timmers; J Boes; C J Melief
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular immunology     Volume:  95     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-07     Completed Date:  1985-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  420-7     Citation Subset:  IM    
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MeSH Terms
Binding, Competitive
Clone Cells / immunology
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic*
Epitopes / genetics*
H-2 Antigens / genetics*,  immunology
Haptens / immunology
Leukocyte Count
Mice, Mutant Strains
Nitrobenzenes / immunology*
Stem Cells / immunology
T-Lymphocytes, Cytotoxic / immunology*
Trinitrobenzenes / immunology*
Reg. No./Substance:
0/Epitopes; 0/H-2 Antigens; 0/Haptens; 0/Nitrobenzenes; 0/Trinitrobenzenes; 0/histocompatibility antigen H-2D(b)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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