Document Detail

H-2 antigen variants in a cultured heterozygous mouse leukemia cell line. VI. Rate of emergence of the hemizygous variants and evidence that the variants preexist the selection.
MedLine Citation:
PMID:  22457915     Owner:  NLM     Status:  In-Process    
The rates of emergence of H-2b- and H-2d- variants from an H-2b+/ H-2d+ heterozygous mouse leukemia cell line were determined by fluctuation analyses. The results show that the wild type cells throw off the H-2b- variants at about 10(-5) per cell per generation and the H-2d- variants at 10(-6) per cell per generation. The reason for this tenfold difference in the rates for the two symmetrical variants is not clear. The fluctuation analyses also indicate that the variants exist in the wild type population prior to exposure to the selective agents.
T V Rajan; E D Halay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunogenetics     Volume:  10     ISSN:  0093-7711     ISO Abbreviation:  Immunogenetics     Publication Date:  1980  
Date Detail:
Created Date:  2012-03-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420404     Medline TA:  Immunogenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-22     Citation Subset:  IM    
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
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