Document Detail


Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9.
MedLine Citation:
PMID:  18507059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gypenosides (Gyp), components of Gynostemma pentaphyllum Makino, were found to induce suppression of human tongue squamous cell carcinoma SCC4 cell growth and induce apoptosis in response to overexpression of reactive oxygen species, calcium (Ca(+2)) and to decrease mitochondrial membrane potential in vitro. In this study, the effect of Gyp on cell migration and invasion of human tongue SCC4 cells was examined. SCC4 cells treated in vitro with Gyp migrated and invaded less than cells treated with phosphate-buffered saline (PBS) as a control. Gyp inhibited migration and invasion by down-regulating the production of RAS, NFkappaB, COX2, ERK1/2 and MMP-9 relative to PBS only. These results show that Gyp inhibits invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis.
Authors:
Kung-Wen Lu; Ming-Li Tsai; Jung-Chou Chen; Shu-Chun Hsu; Te-Chun Hsia; Meng-Wei Lin; An-Cheng Huang; Yung-Hsien Chang; Siu-Wan Ip; Hsu-Feng Lu; Jing-Gung Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  28     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-06-18     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1093-9     Citation Subset:  IM    
Affiliation:
Chinese Medical Research Institute, China Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / enzymology*,  pathology*
Cell Line, Tumor
Cell Movement
Down-Regulation
Gynostemma
Humans
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 9 / metabolism*
Plant Extracts / pharmacology
Protein-Serine-Threonine Kinases / metabolism*
Tongue Neoplasms / enzymology*,  pathology*
Chemical
Reg. No./Substance:
0/Plant Extracts; 0/gypenoside; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.25/NF-kappa B kinase; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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