| Gynecologic surveillance of women on tamoxifen. | |
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MedLine Citation:
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PMID: 7956197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the gynecologic surveillance practices of Connecticut physicians regarding asymptomatic, postmenopausal women receiving tamoxifen for breast cancer management prior to and following a National Cancer Institute (NCI) directive recommending ongoing study and annual pelvic examinations. MATERIALS AND METHODS: An anonymous survey of 110 Connecticut medical oncologists, and 306 gynecologists was completed. RESULTS: Sixty-three of 110 (57.3%) medical oncologists and 134 of 306 (43.8%) gynecologists responded to the survey. Prior to the NCI directive, 51 (81.0%) of the medical oncologists referred patients for annual gynecologic surveillance. A pelvic examination and Papanicolaou smear were anticipated. Following the NCI directive, 29 (46.0%) routinely expected an endometrial biopsy and 17 (27.0%) expected a pelvic ultrasound evaluation. Prior to the directive, 96 (71.6%) gynecologists recommended annual gynecologic surveillance and 35 (26.1%) recommended it semiannually. Following the directive, semiannual evaluation was recommended by 52 (38.8%). Prior to the directive, 11 gynecologists (8.2%) recommended annual endometrial biopsies and 21 (15.7%) pelvic ultrasound examinations. Following the directive these recommendations increased to 24.6% and 59.7% respectively. If the endometrium was 5-8 mm in maximum thickness by ultrasound evaluation, 54.4% of gynecologists recommended endometrial sampling. CONCLUSION: Women receiving tamoxifen are now undergoing increased gynecologic surveillance. A rationale for annual evaluation of asymptomatic postmenopausal patients based on endometrial thickening by ultrasound examination is presented. |
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Authors:
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P E Schwartz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Connecticut medicine Volume: 58 ISSN: 0010-6178 ISO Abbreviation: Conn Med Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-12-27 Completed Date: 1994-12-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372745 Medline TA: Conn Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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drug therapy* Female Humans Middle Aged Neoplasms, Second Primary / chemically induced, prevention & control* Physical Examination* Postmenopause Tamoxifen / adverse effects, therapeutic use* Uterine Neoplasms / chemically induced, prevention & control* |
| Chemical | |
Reg. No./Substance:
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10540-29-1/Tamoxifen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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